Sistema de Información de Ciencia y Tecnología

Implicaciones biológicas de poliparasitismo

Nombre Abreviado 388 POLIPARASIT
Financiamiento ASDI
Convocatoria Programa UMSA - ASDI 2013 - 2017
Categoria y Convocatoria del proyecto Programa UMSA - ASDI
Duración Inicio: 01/01/2013 Fin: 31/12/2017
Tipo de Investigación
Datos SIGEP:
Unidad ejecutora	Programa	Sub-programa	Proyecto	Actividad
95	51	0	0000	388
Resumen del Proyecto
The outcome of an infection is influenced by multiple genetic and environmental factors. How the
    combined impact of more than one factor influence infection is at large unknown. Intestinal parasitic
    infections by helminths are very common in rural communities of Bolivia, where lack of clean   
    water, proper housing and sewage systems allow continuous transmission of helminthes. In this
    project we aim to understand how gastro-intestinal parasitic infections influence and are influenced
     by nutritional status and if the combination of malnutrition and intestinal parasitic infection is a risk
     factor for morbidity due to infection with trypanosomatides T. cruzi and Leishmania sp. in
     school children in 3 regions characterized by the different prevalence of T. cruzi, Leishmania and
     helminth infections.
 
In animal models we will explore how malnourishment influences the outcome of Leishmania and T. cruzi infections, two related parasitic infections, which are endemic in Bolivia. The outcome of these infections will be studied in mice fed with diets lacking selective nutrients, or in animals genetically...Ver mas
The outcome of an infection is influenced by multiple genetic and environmental factors. How the
    combined impact of more than one factor influence infection is at large unknown. Intestinal parasitic
    infections by helminths are very common in rural communities of Bolivia, where lack of clean   
    water, proper housing and sewage systems allow continuous transmission of helminthes. In this
    project we aim to understand how gastro-intestinal parasitic infections influence and are influenced
     by nutritional status and if the combination of malnutrition and intestinal parasitic infection is a risk
     factor for morbidity due to infection with trypanosomatides T. cruzi and Leishmania sp. in
     school children in 3 regions characterized by the different prevalence of T. cruzi, Leishmania and
     helminth infections.
 
In animal models we will explore how malnourishment influences the outcome of Leishmania and T. cruzi infections, two related parasitic infections, which are endemic in Bolivia. The outcome of these infections will be studied in mice fed with diets lacking selective nutrients, or in animals genetically deficient in molecules central for effective regulation of the protein and carbohydrate metabolism.  
 
The project will be divided into two parts, in Bolivia clinico-epidemiological studies in schoolchildren will provide information on nutritional status and how this correlates with polyparasitism and different immune parameters. The other part, which primarily will be conducted at the Dept. of Microbiology, Tumor and Cell Biology, KI, is an experimental animal set up, where the impact of the most common nutritional deficiencies of poor populations can be tested on trypanosome infections in a mono or polyparasitic context.
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Objetivos

Objetivo General

• As a whole, the present research work is aimed at improving the health of Bolivian schoolchildren from rural areas of highland and tropics, and training of students in the framework of this program. Furthermore, these collaborative studies will allow a more realistic approach to the study of polyparasitism and trypanosomal infections in Bolivia, where multiple intestinal parasite infections are the rule in poor rural communities. This approach drives the pursuit of novel avenues that can impact those living with multiple parasite infections and permit acquaintance of the future PhD student with experimental set ups and techniques for examining parasitological, immunological, and nutritional parameters in children´s natural infections and experimental models of polyparasitism.

Objetivos Especificos

• Improve understanding of associated nutritional status, immune parameters, and risks of disease of schoolchildren and youngsters with gastrointestinal infections and co-infections with Leishmania from the study site (Caranavi)

Participantes

Coordinador Celeste del Pilar Rodriguez Quevedo

Co-cordinador

- Participantes del proyecto

Nombre	Grado Académico	Cargo	Cédula de identidad
Erick Castillo Laura	Licenciatura	Apoyo administrativo (Categoria D)
Celeste del Pilar Rodriguez Quevedo	Post. Doctorado Ph.D.	Coordinador (Categoria D)
María Graciela Terán Vásquez	Maestria	Doctorando (Categoria D)
José Armando Rodríguez Zeballos	Tecnico	Investigador (Categoria D)
Washington Roosevelt Cuña del Longo	Doctorado Ph.D.	Investigador (Categoria D)
Ceilan Pamela Apaza Lopez	Doctorado Ph.D.	Investigador (Categoria D)
Yvonee C. Contreras Tapia	Tecnico Superior	Investigador (Categoria D)
Ivonee Clorinda Contreras Tapia	Tecnico	Investigador (Categoria D)

- Colaboradores del proyecto

Nombre	Grado Académico	Cargo	Cédula de identidad
Ruben Choque Condori [email protected]		Chofer (Categoria D)
Hermenegildo Fernandez Callisaya	Bachiller	Chofer (Categoria D)
Celeste del Pilar Rodriguez Quevedo [email protected]	Post. Doctorado Ph.D.	Supervisor ()
Martin Rottenberg		Supervisor ()

Unidades Participantes

Unidad Proponente Laboratorio de Inmunologia Parasitaria del Departamento de Patologia

Unidad Contraparte Karolinska Institutet

+ Unidades Co-Ejecutoras

Nombre de la Unidad	Responsable de la Unidad

Lineas de Investigación